1.
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 251-253, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-326780
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of Runing II on expression of vascular endothelial growth factor (VEGF) in transplanted tumor of mammary cancer MA-891 in TA2 mice.</p><p><b>METHODS</b>The MA-981 mice mammary cancer cell cultivated in vivo was inoculated into the right axilla subcutaneously of TA2 mice to establish the transplanted tumor model, which were treated with Runing II.</p><p><b>RESULTS</b>Runing II could inhibit the growth of transplanted tumor and the occurrence of lung metastasis (P < 0.05), reduce the expression of VEGF protein and mRNA in tumor tissue (P < 0.05).</p><p><b>CONCLUSION</b>Runing II could reduce the expression of VEGF protein and mRNA, hence to inhibit the growth of tumor and lung metastasis.</p>